Summary: In a pioneering study, researchers designed a wireless brain-spine interface enabling a paralyzed man to walk naturally again. The ‘digital bridge’ comprises two electronic implants — one on the brain and another on the spinal cord — that decode brain signals and stimulate the spinal cord to activate leg muscles.
Remarkably, the patient experienced significant recovery in sensory perceptions and motor skills, even when the interface was off. The team hopes to extend the technology’s applications to include restoring arm and hand functions, and assisting stroke patients.
- The brain-spine interface is composed of two electronic implants that work together to decode brain signals and stimulate the spinal cord, resulting in the activation of leg muscles and enabling natural movement.
- The patient experienced significant improvement in sensory perceptions and motor skills, indicating potential development of new nerve connections even when the interface was not active.
- The team plans to explore applications of the technology to restore other functions and assist stroke patients, and there are ongoing efforts to commercialize the technology globally through ONWARD Medical, in partnership with CEA and EPFL.
Neuroscientists and neurosurgeons from EPFL/CHUV/UNIL and CEA/CHUGA/UGA report in the journal Nature that they have re-established the communication between the brain and spinal cord with a wireless digital bridge, allowing a paralyzed person to walk again naturally.
“We have created a wireless interface between the brain and the spinal cord using brain-computer interface (BCI) technology that transforms thought into action.”, summarizes Grégoire Courtine, Professor of Neuroscience at EPFL, CHUV and UNIL. Published in the journal Nature,
“Walking naturally after spinal cord injury using a brain-spine interface” presents the situation of Gert-Jan, 40 years old, who suffered a spinal cord injury following a bicycle accident that left him paralyzed.
“The digital bridge enabled him to regain natural control over the movement of his paralyzed legs, allowing him to stand, walk, and even climb stairs. Gert-Jan explains that he has recovered the pleasure of being able to share a beer standing at a bar with friends : “This simple pleasure represents a significant change in my life”.
A digital bridge involving two electronic implants: one on the brain, the other on the spinal cord
To establish this digital bridge, two types of electronic implants are needed. Neurosurgeon Jocelyne Bloch, who is a professor at CHUV, UNIL and EPFL, explains: “We have implanted WIMAGINE® devices above the region of the brain that is responsible for controlling leg movements.
“These devices developed by the CEA allows to decode the electrical signals generated by the brain when we think about walking. We also positioned a neurostimulator connected to an electrode array over the region of the spinal cord that controls leg movement.
Guillaume Charvet, head of the BCI program at CEA, adds: “Thanks to algorithms based on adaptive artificial intelligence methods, movement intentions are decoded in real time from brain recordings.”
These intentions are then converted into sequences of electrical stimulation of the spinal cord, which in turn activate leg muscles to achieve the desired movement. This digital bridge operates wirelessly, allowing the patient to move around independently.
Recovery of neurological functions
Rehabilitation supported by the digital bridge enabled Gert-Jan to recover neurological functions that he had lost since his accident.
Researchers were able to quantify remarkable improvements in his sensory perceptions and motor skills, even when the digital bridge was switched off. This digital repair of the spinal cord suggests that new nerve connections have developed.
At this stage, the digital bridge has only been tested in one person. Jocelyne Bloch and Grégoire Courtine explain that, in the future, a comparable strategy could be used to restore arm and hand functions.
They add that the digital bridge could also be applied to other clinical indications, such as paralysis due to stroke.
The company ONWARD Medical, along with CEA and EPFL has received support from the European Commission trough its European Innovation Council (EIC) to develop a commercial version of the digital bridge, with the goal of making the technology available worldwide.
This work is supported by:
Defitech Foundation, Rolex Award for Enterprise, International Foundation for Research in Paraplegia, Translational Medical Research Award 2021 from the Leenaards Foundation, Pictet Group Charitable Foundation, ONWARD medical, Medtronic, the Swiss National Science Foundation through the National Centre of Competence in Research in Robotics (51NF40-185543), Sinergia (CRSII5-183519), the Lead Agency Program with the French National Research Agency (Think2Move SNF-32003BE-205563, ANR-21-CE19-0038), A F Harvey Prize award, Swiss Innovation Agency InnoSuisse (CTI-41871.1 IP-LS Bridge), Eurostars (E!12743 Confirm and E!113969 Prep2Go), the European Commission (ERC-2019-PoC Braingait 875660, EIC 2021-TransitionChallenges-01-01 ReverseParalysis 101057450, Horizon-EIC-2021-Pathfinderchallenges-01-02 NEMO-BMI 101070891), Fonds de dotation Clinatec (WIMAGINE implant development) and Institut Carnot Leti.
About this neurotech research news
Original Research: Open access.
“Walking naturally after spinal cord injury using a brain–spine interface” by Henri Lorach et. al. Nature
Walking naturally after spinal cord injury using a brain–spine interface
A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis.
Here, we restored this communication with a digital bridge between the brain and spinal cord that enabled an individual with chronic tetraplegia to stand and walk naturally in community settings.
This brain–spine interface (BSI) consists of fully implanted recording and stimulation systems that establish a direct link between cortical signals and the analogue modulation of epidural electrical stimulation targeting the spinal cord regions involved in the production of walking.
A highly reliable BSI is calibrated within a few minutes. This reliability has remained stable over one year, including during independent use at home.
The participant reports that the BSI enables natural control over the movements of his legs to stand, walk, climb stairs and even traverse complex terrains. Moreover, neurorehabilitation supported by the BSI improved neurological recovery. The participant regained the ability to walk with crutches overground even when the BSI was switched off.
This digital bridge establishes a framework to restore natural control of movement after paralysis.